Paul Teesdale-Spittle

Paul Teesdale-Spittle

Job Title

Associate Professor

Biography

My research is primarily focused on the design, synthesis and evaluation of compounds for the treatment of cancer and parasite infection. To this end, I make use of computational techniques (including molecular modelling of ligand-target interactions and structure activity relationship analysis), chemical synthesis (by solution and solid phase techniques, including parallel combinatorial synthesis), and in vitro assays. Current projects involve inhibitors of glutathione S-transferase enzymes as antiparasitic agents, peloruside and its analogues and bioreducible anthraquinone N-oxide topoisomerase inhibitors as anticancer agents. I am also interested in understanding and harnessing WW domains, which are associated with protein recognition and binding.

Expertise
  • Computational techniques for the treatment of cancer and parasite infection